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BIOCHEMISTRY TOPICS

BLOCK 1:

  • Structure of DNA and chromosomes
  • DNA replication, recombination and repair
  • RNA synthesis and processing in bacteria and eukaryotic cells
  • Transcription and RNA metabolism
  • The genetic code
  • Molecular mechanism of protein synthesis
  • Genetic code and translation
  • Gene regulation of prokaryotic and eukaryotic cells
  • Gene expression
  • Recombinant DNA technology
  • Genetic engineering in medicine
  • Molecular medicine
  • Chemical bonds and ionizable groups
  • Protein structure
  • The amino acids
  • Protein structure analysis
  • Enzymes
  • Catalysis and inhibitors
  • Hemoglobin and myoglobin structure
  • Myosin-based molecular motors
  • Sequence-specific DNA binding proteins and collagen

BLOCK 2:

  • Bioenergetics: basic concepts of energy generation
  • ATP formation in mitochondria (Oxidative phosphorylation)
  • Generation of energy form Acetyl CoA (TCA cycle)
  • Fatty acid catabolism
  • Generation of energy from carbohydrates
  • Fatty acid oxidation
  • Glycolysis and CHO metabolism
  • Amino acid catabolism
  • Regulation of energy metabolism
  • Basic concepts in the regulation of storage and mobilization of energy reserves
  • Glycogen storage and breakdown
  • Fatty acid synthesis and storage
  • Tryglyceride metabolism
  • Ketone body metabolism
  • Protein turnover
  • Regulation of metabolism
  • Metabolic disorders

BLOCK 3:

  • Amino acid biosynthesis
  • One-carbon metabolism
  • Amino acid-derived products
  • Purine and pyrimidine metabolism
  • Phospholipids
  • Phospholipases, eicosanoic acids, phingolipids
  • Metabolism of cholesterol
  • Lipid digestion and transport
  • Steroid hormones and proteoglycans
  • Glycoproteins
  • Membrane structure and targeting
  • Membrane transport
  • Cell signaling mechanisms
  • Nutrition: macronutrients, vitamins and minerals

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